Asthma represents a public health problem and traditionally is classified as an atopic disease, where the allergen can induce\nclinical airway inflammation, bronchial hyperresponsiveness, and reversible obstruction of airways. Studies have demonstrated the\npresence of T-helper 2 lymphocytes in the lung of patients with asthma. These cells are involved in cytokine production that regulates\nimmunoglobulin synthesis. Recognizing that T cell interaction with antigens/allergens is key to the development of inflammatory\ndiseases, the aim of this study is to evaluate the anti-inflammatory potential of cannabidiol (CBD) in this setting. Asthma was\ninduced in 8-week-old Wistar rats by ovalbumin (OVA). In the last 2 days of OVA challenge animals received CBD (5 mg/kg, i.p.)\nand were killed 24 hours after. The levels of IL-4, IL-5, IL-13, IL-6, IL-10, and TNF-
Loading....